High mechanical efficiency of the cross-bridge powerstroke in skeletal muscle

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چکیده

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The cross-bridge cycle and skeletal muscle fatigue.

The functional correlates of fatigue observed in both animals and humans during exercise include a decline in peak force (P0), maximal velocity, and peak power. Establishing the extent to which these deleterious functional changes result from direct effects on the myofilaments is facilitated through understanding the molecular mechanisms of the cross-bridge cycle. With actin-myosin binding, the...

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We thank Dr. Ortega for the opportunity to debate the concept that aging affects exercise efficiency. From the outset we must acknowledge that, indeed, some studies report an age-related reduction task efficiency during walking and other rather complex tasks (2, 12, 20, 21). However, in contrast, our recent study of leg cycling in centenarians (28), as well as other work focused more specifical...

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Point: skeletal muscle mechanical efficiency does increase with age.

We thank Dr. Ortega for the opportunity to debate the concept that aging affects exercise efficiency. From the outset we must acknowledge that, indeed, some studies report an age-related reduction task efficiency during walking and other rather complex tasks (2, 12, 20, 21). However, in contrast, our recent study of leg cycling in centenarians (28), as well as other work focused more specifical...

متن کامل

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ژورنال

عنوان ژورنال: Journal of Experimental Biology

سال: 2003

ISSN: 1477-9145,0022-0949

DOI: 10.1242/jeb.00232